Category: Peptides Research
Research articles and educational content on peptides and longevity compounds, authored and reviewed by Dr. James, a board-certified neurosurgeon trained at Yale University, and Dr. Tom, a licensed pharmacist. All content is for research and educational purposes only.
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NAD+ and Brain Aging Research: How This Coenzyme Influences Neurological Longevity
During my residency, a senior surgeon told me that the brain is the most metabolically expensive organ in the body — accounting for roughly 20% of total caloric expenditure while making up only 2% of body weight. That metabolic intensity is why brain cells are among the first to show signs of aging, and why…
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TB-500 and Joint Recovery Research: What Thymosin Beta-4 Data Reveals About Connective Tissue Repair
The patient had torn his ACL six months before we first spoke — and despite successful surgery, his recovery had stalled. The connective tissue wasn’t knitting the way it should. I’ve seen this pattern more times than I can count: the acute phase heals, but the deep remodeling that turns scar tissue into functional tissue…
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CJC-1295 Peptide Research: A Neurosurgeon’s Look at GHRH Analogues and Growth Hormone Pulse Amplification
There’s a moment in the OR — maybe you’ve had a version of it too — where you step back from what you’re doing and wonder whether the body could just… do this faster. Regenerate more efficiently. Restore what time and injury have worn down. For me, that question eventually led to the research literature…
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BPC-157 Peptide Research: A Neurosurgeon’s Look at Nerve Regeneration and Systemic Healing
I’ve spent over two decades watching the nervous system heal — or fail to. As a neurosurgeon, most of my professional life revolves around tissue that the medical establishment long considered essentially non-regenerative. So when a colleague handed me a stack of animal studies on a peptide derived from gastric juice — of all places…
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SS-31 Peptide Research: A Neurosurgeon’s Look at Mitochondrial Targeting, Cardiolipin Protection, and Cellular Bioenergetics
The patient was a 58-year-old marathoner. Pre-op, she had run four marathons a year. Eighteen months after her spinal procedure — technically successful, no complications — she came back describing something she called “cellular exhaustion.” Not fatigue from exertion. Fatigue from existing. That description sent me back into the mitochondrial biology literature, and eventually to…
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Epithalon Peptide Research: A Neurosurgeon’s Look at Telomeres, the Pineal Gland, and Cellular Longevity
A 71-year-old retired oncologist walked into my office last year with clean imaging, no deficits, and one question I wasn’t expecting: “What do you know about the pineal gland and aging?” He’d been reading the longevity literature — seriously, methodically, the way only a physician-turned-patient can. He mentioned Epithalon. I’ll be honest: I gave him…
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Selank Peptide Research: A Neurosurgeon’s Investigation into Tuftsin-Derived Anxiolysis, BDNF, and Cognitive Resilience
The patient had no abnormal imaging. No lesion I could excise, no pressure I could relieve. She was a 47-year-old attorney who described her mind as “perpetually stuck in threat mode” — high-functioning by every external measure, but chronically dysregulated in ways that affected her memory, her sleep, and her quality of life. That case…
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Semax Peptide Research: A Neurosurgeon’s Investigation into BDNF, Neuroprotection, and Cognitive Resilience
Two years ago, I sat across from a patient in post-op — a 54-year-old engineer, technically a textbook success after a meningioma resection — and he told me something that stayed with me: “My hands work fine. But I feel like I’m thinking through fog.” His imaging was clean. His motor scores were perfect. But…
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GHK-Cu Copper Peptide Research: A Neurosurgeon’s Look at Gene Activation, Tissue Repair, and Antioxidant Signaling
I didn’t expect a molecule my own body produces to stop me cold mid-research session. But that’s what happened with GHK-Cu. I was reviewing post-surgical tissue repair literature — something I do regularly as a neurosurgeon — and I kept running into citations for this small copper-binding tripeptide with an almost absurdly broad reach. The…
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Selank Peptide Research: A Neurosurgeon’s Look at Anxiety, BDNF, and the Tuftsin-Derived Anxiolytic
A few years ago, a psychiatrist colleague sent me a paper on Selank with a note that said simply: “You’ll find this interesting.” He was right. As someone who spends a lot of time thinking about the neurological consequences of chronic stress — the inflammation, the structural changes, the cognitive toll — I’ve long been…
