Category: Peptides Research
Research articles and educational content on peptides and longevity compounds, authored and reviewed by Dr. James, a board-certified neurosurgeon trained at Yale University, and Dr. Tom, a licensed pharmacist. All content is for research and educational purposes only.
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GHRP-2 vs GHRP-6: Comparing Two Growth Hormone Releasing Peptides in Research
Written by: Dr. James Nguyen, MD (Neurosurgeon) Growth hormone releasing peptides (GHRPs) are among the oldest synthetic peptide tools in endocrinology. GHRP-6 was described in the early 1980s, and GHRP-2 followed as a more potent analogue. Both act on the same receptor, both stimulate growth hormone (GH) release, and both are still used to study…
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Oxytocin Research: What the Neuropeptide Data Reveals About Social Behavior, and Where the Evidence Falls Short
Written by: Dr. James Nguyen, MD (Neurosurgeon) Oxytocin may be the best-known peptide outside the research world. Headlines have called it the “love hormone,” the “trust molecule,” and the “cuddle chemical.” Behind those labels is a large and serious literature on a nine-amino-acid neuropeptide that acts in the brain and throughout the body. Oxytocin research…
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ARA-290 (Cibinetide) Research: What the Innate Repair Receptor Data Reveals
Written by: Dr. James Nguyen, MD (Neurosurgeon) Erythropoietin (EPO) is best known for its role in red blood cell production. Over the past two decades, researchers have also documented a second role. EPO produced locally in tissue appears to protect cells from injury, and it does so through a different receptor from the one that…
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DSIP Research: What Scientists Have (and Haven’t) Learned About Delta Sleep-Inducing Peptide
Written by: Dr. James Nguyen, MD (Neurosurgeon) Few peptides have a name as confident as delta sleep-inducing peptide. When DSIP was described in 1977, it looked like a candidate for something researchers had chased for most of the twentieth century: a circulating “sleep factor” that could carry a sleep signal through the blood. Nearly fifty…
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The Future of Peptide Research: Emerging Trends in Synthesis and Delivery
Peptide research continues to evolve rapidly, with new synthesis technologies and delivery approaches expanding what is possible in laboratory settings. Emerging trends in peptide research include advances in automated and flow-based synthesis, novel delivery formulations designed to improve stability, and computational tools that help predict peptide structure and behavior before laboratory testing even begins. Together,…
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Understanding Peptide Purification Techniques Beyond HPLC
High-performance liquid chromatography is a widely used peptide purification method, but it is far from the only technique researchers rely on to isolate and refine peptide samples. Beyond HPLC, peptide purification techniques include ion-exchange chromatography, size-exclusion chromatography, and solid-phase extraction, each separating peptides based on different physical or chemical properties such as charge, size, or…
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Peptide Receptor Pharmacology 101: Agonists, Antagonists, and Binding Affinity
Understanding how a peptide interacts with its target receptor is central to interpreting its potential mechanism of action in preclinical research. Peptide receptor pharmacology examines how peptides bind to and influence receptors, generally categorized as agonists, which activate a receptor’s signaling response, or antagonists, which block it. Binding affinity describes how strongly a peptide attaches…
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Understanding Peptide Classes: Hormone Analogs, Neuropeptides, and Structural Peptides
Peptides studied in research settings vary widely in function, and understanding the broad classes they fall into helps clarify why they are studied differently across disciplines. Peptides are generally grouped into functional classes such as hormone analogs, neuropeptides, and structural peptides, each defined by the biological role the peptide mimics or influences in preclinical research.…
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The Difference Between Peptides and Proteins: A Structural Overview
Peptides and proteins are often discussed together, and while they share the same basic chemical building blocks, they differ in important structural respects. Peptides and proteins are both chains of amino acids linked by peptide bonds, but they are generally distinguished by size: peptides typically consist of fewer than 50 amino acids, while proteins are…
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Peptide Nomenclature Explained: How to Decode Compound Names
Peptide names can look like a confusing string of letters and numbers, but most follow a logical naming system once the underlying conventions are understood. Peptide nomenclature typically follows conventions set by international bodies such as IUPAC and the INN system, incorporating information about amino acid sequence, chain modifications, and sometimes the peptide’s structural class,…
