Category: Peptides Research
Research articles and educational content on peptides and longevity compounds, authored and reviewed by Dr. James, a board-certified neurosurgeon trained at Yale University, and Dr. Tom, a licensed pharmacist. All content is for research and educational purposes only.
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GHK-Cu Peptide Research: 5 Weeks, 471 Upvotes, and What the Science Actually Shows
A few days ago, a post on r/Peptides documenting someone’s 5-week experience with GHK-Cu hit 471 upvotes. I noticed it because my inbox lit up — researchers, colleagues, and a few curious patients all sending me the same link. That kind of signal in the peptide community doesn’t happen by accident. It happens when something…
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NAD+ vs NMN: Which Is Better in Research Models?
NAD+ vs NMN: Which Is Better in Research Models? The NAD+ vs NMN debate is one of the most common questions I receive from researchers entering the longevity biology space. The direct answer: these aren’t competitors — they’re different points on the same biosynthetic pathway, and the “better” choice depends entirely on your research question.…
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PT-141 and Melanocortin Receptor Research: CNS Mechanisms Explained
PT-141 and Melanocortin Receptor Research: CNS Mechanisms Explained PT-141 (Bremelanotide) is one of the most pharmacologically interesting peptides in research because it works entirely through the central nervous system — not through peripheral vasculature like most autonomic-affecting compounds. Understanding its melanocortin receptor pharmacology reveals important principles about hypothalamic biology. The key finding: PT-141 activates MC3R…
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CJC-1295: What Research Reveals About This Growth Hormone Releasing Hormone Analog
As a neurosurgeon trained at Yale, I’ve followed the research on growth hormone releasing hormone (GHRH) analogs closely — not just for their implications in metabolic medicine, but for what they reveal about how the brain and endocrine system communicate. CJC-1295 is one of the most extensively studied synthetic GHRH analogs in preclinical and early…
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Selank Peptide: Anxiety Research and Cognitive Science
There’s a phrase that keeps coming up in neuroscience research circles: “anxiolytic without sedation.” For decades, that combination seemed almost contradictory — everything that calmed the nervous system also seemed to slow it down. Then researchers started looking more closely at a small synthetic peptide called Selank, and the picture started to get considerably more…
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MOTS-c: The Mitochondrial Peptide and Longevity Research
Something quietly remarkable happened in mitochondrial biology research in 2015: scientists discovered that mitochondria — long understood as the cell’s energy factories — also produce their own signaling peptides. One of these, MOTS-c, is a 16-amino-acid molecule encoded within mitochondrial DNA itself, and the metabolic effects researchers have observed in preclinical models are hard to…
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Best Peptides for Muscle Recovery Research: 2026 Scientific Overview
Best Peptides for Muscle Recovery Research: 2026 Scientific Overview Researchers entering musculoskeletal peptide biology face a crowded field with varying levels of evidence behind different compounds. Having reviewed this literature extensively from both a surgical and scientific perspective, I can offer a clear framework for understanding which peptides have the strongest research rationale for muscle…
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SS-31: Mitochondrial Protection Research and the Science of Cardiolipin Targeting
The mitochondrial inner membrane is one of the most selectively permeable structures in human biology, and SS-31 exploits this specificity in a way that most peptide researchers find worth studying closely. Unlike compounds that bind to surface receptors, SS-31 targets cardiolipin — a phospholipid concentrated almost exclusively in the inner mitochondrial membrane — stabilizing it…
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Thymosin Alpha-1 and Immune System Research: What the Science Shows
Thymosin Alpha-1 and Immune System Research: What the Science Shows Among immune-modulating peptides, thymosin alpha-1 has one of the most compelling research profiles — supported by clinical trial data from multiple countries and a pharmacological mechanism that directly targets T-cell biology. For researchers working in immunology, this peptide offers both mechanistic clarity and substantial human…
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Ipamorelin vs Sermorelin: Comparing Growth Hormone Secretagogues in Research
Ipamorelin vs Sermorelin: Comparing Growth Hormone Secretagogues in Research Growth hormone secretagogue research is often confused by the variety of peptides available with overlapping effects. Ipamorelin vs sermorelin is a comparison that deserves careful mechanistic analysis — because while both stimulate pituitary GH release, they do so through entirely different receptor systems, with different selectivity…
