Category: Peptides Research
Research articles and educational content on peptides and longevity compounds, authored and reviewed by Dr. James, a board-certified neurosurgeon trained at Yale University, and Dr. Tom, a licensed pharmacist. All content is for research and educational purposes only.
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SS-31 Peptide Research: The Mitochondria-Targeting Compound Scientists Are Studying
If you want to understand aging at the deepest level, you have to go inside the cell. Not to the nucleus — though that’s important — but to the mitochondria. These ancient organelles, remnants of an endosymbiotic event billions of years ago, are where energy is made, where reactive oxygen species accumulate, and where the…
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IGF-1 LR3 Research: Understanding the Long-Arginine-3 Growth Factor Analog
Some peptides make you reconsider how growth works at the fundamental cellular level. IGF-1 LR3 is one of them. I first encountered it in the context of tissue repair research — specifically, why some tissues regenerate robustly after injury while others seem to plateau. The answer, in many cases, traces back to insulin-like growth factor…
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Sermorelin Research: What the Science Reveals About This GHRH Analog
The first time I reviewed a patient’s IGF-1 panel and saw those numbers bottom out in a 45-year-old, I started asking different questions. Not just about hormone replacement, but about the upstream signals — the releasing hormones, the pulsatile rhythms, the hypothalamic-pituitary axis that orchestrates so much of how the body ages. That’s where Sermorelin…
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Thymalin Research: What Scientists Are Discovering About This Thymic Peptide
There’s a moment in every researcher’s journey when a compound stops being just a name in a paper and starts feeling genuinely important. Thymalin had that effect on me. As someone who spent years in the operating room dealing with the consequences of immune dysregulation — post-surgical infections, delayed healing, the slow deterioration of aging…
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Epithalon Research: What Scientists Are Discovering About This Telomere-Activating Peptide
If there’s one question that has quietly defined the outer edge of longevity science over the past thirty years, it’s this: can we do anything about telomeres? As a neurosurgeon who spends a significant amount of time in the aging biology literature, I’ve watched the telomere story evolve from theoretical curiosity to active research frontier…
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Ipamorelin Research: What Scientists Are Discovering About This Selective Growth Hormone Secretagogue
There’s a moment in research when a compound stops being just another sequence of amino acids and starts looking genuinely interesting. For me, that moment with ipamorelin came when I read how selectively it stimulates growth hormone release — without the hormonal side effects that plagued earlier GH secretagogues. As a neurosurgeon who tracks peptide…
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Tesamorelin Research: Growth Hormone Release, Mechanisms, and What the Studies Show
Tesamorelin is an FDA-approved GHRH analog with extensive human clinical data. Full breakdown of the GH-IGF-1 axis, visceral fat reduction trials, cognitive research, and comparison with ipamorelin.
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Thymosin Alpha-1 Research: Immune Modulation, Mechanisms, and What the Science Shows
Thymosin Alpha-1 has decades of clinical data across hepatitis, cancer immunotherapy, and immune deficiency research. Full breakdown of T-cell modulation mechanisms, TLR9 agonism, hepatitis trial data, and COVID-19 research.
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PT-141 (Bremelanotide) Research: Mechanisms, Studies, and What the Science Shows
PT-141 acts on melanocortin receptors in the brain — not peripheral vasculature. A full breakdown of MC4R mechanisms, FDA approval data, clinical trial results, and how it differs from vascular-targeting compounds.
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NAD+ Research: Aging, Cellular Energy, and What the Science Shows
NAD+ sits at the center of aging biology research. Here’s the complete breakdown: why it declines with age, sirtuin activation, PARP competition, mitochondrial function, and key human study results.
